Translating cancer biology into medicines

Cell cycle pioneers improving patients' healthcare
with innovative medicines

Cyclacel Pharmaceuticals, Inc. (NASDAQ: CYCC, NASDAQ: CYCCP) is a biopharmaceutical company developing innovative therapies that target various phases of cell cycle control for the treatment of cancer and other serious diseases.

Our strategy is to build a diversified portfolio of novel drug candidates to address areas of high unmet medical needs.

Our Pipeline

Cyclacel is a pioneer in the field of cell cycle biology. Our vision is to improve patient healthcare by translating cancer biology into medicines. We have three programs in development:

  • A transcriptional regulation program is evaluating lead asset fadraciclib (a.k.a CYC065), a dual inhibitor of cyclin dependent kinases (CDK) 2 and 9, in patients with advanced cancers.
  • A DNA damage response program is evaluating a combination regimen of sapacitabine and other approved and/or investigational combinants targeting advanced cancers.
  • A mitosis regulation program is investigating CYC140, a polo-like kinase 1 inhibitor, in cancer patients.

Our clinical programs are enhanced through collaboration with world renowned cancer research organizations such as MD Anderson Cancer Center and Dana Farber Cancer Institute.

Learn more about our assets:


A highly-selective, orally-available, 2nd generation inhibitor of cyclin dependent kinases (CDK) 2 and 9.


An oral nucleoside analogue prodrug that acts through a novel mechanism.


A highly selective inhibitor of a mitotic pathway enzyme polo-like kinase 1.

Common Stock Info




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Interview of President & CEO Spiro Rombotis at the Biotech Showcase 2020, San Francisco

video image of Spiro Rombotis, CEO of Cyclacel
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Russo Partners Cutting Edge Cast Podcast: Cracking the Code of Cancer, an interview with Spiro Rombotis, President and CEO of Cyclacel
New weapons in the battle against cancer. Scientists at Cyclacel Pharmaceuticals are turning the tables on cancer using cell cycle biology. Hear CEO Spiro Rombotis explain how these new approaches might keep cancer in check in this Cutting Edge Cast.
Listen to the interview:
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