Harnessing the cell cycle to treat cancer and other serious diseases

cyclacel homepage hero - employee in lab
cyclacel homepage hero - employee in lab

About Cyclacel

As a clinical-stage, biopharmaceutical company, we develop innovative cancer medicines based on cell cycle, transcriptional regulation, epigenetics and mitosis biology. Cyclacel’s strategy is to build a diversified biopharmaceutical business based on a pipeline of novel drug candidates to address oncology and hematology indications.

Our Science

Cyclacel is a pioneer in the field of cell cycle biology to treat cancer. We use insights in cancer biology to research and develop medicines that address the growing problem of resistance. Cancer cells learn to evade anticancer therapeutics and become resistant to available therapies. We aim to suppress mechanisms of resistance and reactivate the body’s own cell death mechanisms to destroy cancer cells.

Our Pipeline

Consistent with our mission to develop medicines that expand available options for patients, we have 2 orally-available programs in clinical development:

  • Fadraciclib (formerly CYC065), a cyclin dependent kinase (CDK)-2 and-9 inhibitor
  • Plogosertib (formerly CYC140), a polo-like kinase 1 (PLK1) inhibitor


Access the latest publications on fadraciclib, CYC140, sapacitabine and related mode of actions.

Oct 2022

Sarina Piha-Paul et al., A Phase 1/2, Open-label, Multi-center Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Fadraciclib (CYC065), an Oral CDK2/9 Inhibitor, in Subjects with Advanced Solid Tumors and Lymphoma. A poster presentation at the 34th EORTC-NCI-AACR Symposium 26-28 Oct 2022, Abstract 50.

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Mar 2021

Somarelli JA et al., A precision medicine drug discovery pipeline identifies combined CDK2 and 9 inhibition as a novel therapeutic strategy in colorectal cancer. Mol Cancer Ther. 2020, 19: 2516-2527.

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Interested in Learning More About Cyclacel?

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Paul McBarron

Executive Vice President, Chief Financial Officer & Chief Operating Officer​

Mr. McBarron has served as a director of the Company since March 2006. Mr. McBarron joined Cyclacel in January 2002 and has over 30 years of experience with pharmaceutical and biotechnology companies. He has served as a financial executive at Sterling Drug, Sanofi-Winthrop and SmithKline Beecham and, from 1996 to 2001, as a senior member of the finance team at Shire Pharmaceuticals plc, where he held the positions of Director of Corporate Finance and Group Financial Controller. He joined Shire when it was an emerging public company. He qualified as a chartered accountant with Ernst & Young and served on the Scottish Lifesciences Association Board.