Cyclacel
About Cyclacel Pharmaceuticals

Management Team

Spiro Rombotis

President and Chief Executive Officer

Mr. Rombotis joined Cyclacel as its first CEO in 1997 and has over 35 years at three public biotechs and two pharmas. He participated in in-licensing, clinical development, regulatory approval, partnering and commercial launch of several drugs, mainly in inflammation and hematology/oncology, including Abelcet®, Evacet/Myocet®, ProHance®, Remicade® and Reopro®. Major functional roles included international operations and business development as Vice President at Liposome (subsequently acquired by Elan) and previously Vice President in the pharmaceuticals division of Bristol-Myers Squibb. He began his career in the early '80s, after training at Novartis, as one of the first employees of Centocor (subsequently acquired by Johnson & Johnson). He holds an MBA and MPH (Hospital & Health Services Management) with honors, Kellogg School of Management, Northwestern University and a BA, Williams College. He serves on the Board of Trustees of BioNJ, the NJ biotech association.

Paul McBarron

Executive Vice President, Finance and Chief Operating Officer and Secretary

Mr. McBarron has served as a director of the Company since March 2006. Mr. McBarron joined Cyclacel in January 2002 and has over 30 years of experience with pharmaceutical and biotechnology companies. He has served as a financial executive at Sterling Drug, Sanofi-Winthrop and SmithKline Beecham and, from 1996 to 2001, as a senior member of the finance team at Shire Pharmaceuticals plc, where he held the positions of Director of Corporate Finance and Group Financial Controller. He joined Shire when it was an emerging public company. He qualified as a chartered accountant with Ernst & Young and served on the Scottish Lifesciences Association Board.

Mark H. Kirschbaum, M.D.

Senior Vice President, Chief Medical Officer

Dr. Kirschbaum joined Cyclacel as Senior Vice President & Chief Medical Officer in October, 2020. Dr. Kirschbaum is a highly experienced hematologist/oncologist with over 30 years of experience in molecular medicine, new drug development, clinical trial design and patient care. He has management experience in both academic research and clinical and pharmaceutical settings. He served as Vice President, Hematology/ Oncology at ArQule Inc., where he managed the development of their BTK inhibitor ARQ531 for hematological indications, including CLL. Previously, he was Senior Medical Director with global clinical development responsibilities at Daiichi-Sankyo, Taiho Pharmaceuticals and BeiGene, USA, where he led the clinical development of novel compounds in various solid tumors and hematological malignancies. Dr. Kirschbaum has also served as Professor of Medicine, Director of Experimental Therapeutics, Hematology at the Monter Cancer Center/NSLIJHS; Professor of Medicine, Director Hematologic Malignancies at Penn State, Hershey Cancer Center; Director of Experimental Therapeutics, Nevada Cancer Institute; Director, New Drug Development at the City of Hope National Cancer Center, and Attending Senior Physician, Department of Hematology and Department of Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center. He earned a B.A. from Yeshiva University in New York and received his M.D. from SUNY–Health Sciences Center in Brooklyn. He did his Residency in Internal Medicine at Kings County Hospital Center in New York and has also held a Research Fellowship in Oncology at Fred Hutchinson Cancer Research Center in Seattle.

Judy Chiao, M.D.

Vice President, Clinical Development and Regulatory Affairs

Dr. Chiao joined Cyclacel Pharmaceuticals in December 2004. From September 2002 to December 2004, she was at Aton Pharma, Inc., a wholly owned subsidiary of Merck & Co. Inc., most recently as Vice President, Oncology Clinical Research and Development. Prior to Aton's acquisition by Merck, she was responsible for leading the clinical development of Zolinza, a histone deacetylase inhibitor, for hematologic and solid tumor indications. From July 2000 to December 2001, Dr. Chiao was a Senior Medical Reviewer, Division of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, where she was the agency's primary reviewer for a range of oncology drugs and regulatory subjects. She also presented the FDA's views in several New Drug Application reviews at Oncology Drug Advisory Committees. Dr. Chiao earned her Bachelor of Science in Chemistry (summa cum laude) at Columbia University, New York, and received her medical degree from Harvard Medical School. Her internship and residency in internal medicine was carried out at Columbia-Presbyterian Medical Center, New York and she held a Research Fellowship in Molecular Pharmacology at Sloan Kettering Institute for Cancer Research and a Clinical Fellowship in Hematology/Oncology at Memorial Sloan Kettering Cancer Center both in New York City. She has also been a member of a number of FDA-related working groups and has also been a Core Member of the Pharsight-FDA Cooperative Research and Development Agreement (CRADA) on clinical trial simulation and population pharmacokinetic analysis software for drug development.

Amartya Basu, Ph.D., MBA

Senior Director, Project Management and Business Development

Dr. Basu joined Cyclacel Pharmaceuticals in September 2018. He brings 20+ years of R&D, project/program management and business development experience to Cyclacel. He held various leadership roles in academia, biotech and pharmaceutical companies. Prior to joining Cyclacel, Dr. Basu served as a principal consultant to CMK Select and helped Celgene in the lifecycle management of Istodax, a PTCL/CTCL drug. At Hoffmann La Roche, he was involved in managing various oncology and non-oncology drugs in global development, and served in various due diligence activities, six of which have been integrated into Roche portfolio. He started his industry career at Enzon Pharmaceuticals, Inc. where he led a team of scientists through cutting-edge research and development activities in protein and antibody therapeutics and, secured break-through publications and patents. He received his Executive MBA degree from Rutgers University and earned his Ph.D. in Biochemistry from the University of Medicine and Dentistry of New Jersey (currently under Rutgers University).

 

Research & Development