Cyclacel has contributed to many scientific advancements.
A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers. Mol Cancer Ther. 2021, 20:477-489.
Phase 1 safety, pharmacokinetic and pharmacodynamic study of fadraciclib (CYC065), a cyclin-dependent kinase inhibitor, in patients with advanced cancers (NCT02552953). An oral presentation delivered at the 32nd EORTC/AACR/NCI Virtual Symposium 24-25 Oct 2020.
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. J Clin Invest 2020; https://doi.org/10.1172/JCI134132.
Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biol & Therapy 2020; https://doi.org/10.1080/15384047.2020.1818518.
Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer. PLOS One, July 9, 2020; doi.org/10.1371/journal.pone.0234103.
Strategic combination of the cyclin-dependent kinase inhibitor CYC065 with venetoclax to target anti-apoptotic proteins in chronic lymphocytic leukemia. Proc. Ann. Meeting AACR, 2018, Apr 14-18; Chicago, IL, Abstract 3905.
Phase I safety, pharmacokinetic and pharmacodynamic study of CYC065, a cyclin-dependent kinase inhibitor, in patients with advanced cancers (NCT02552953). Proc. Ann. Meeting AACR, 2018, Apr 14-18; Chicago, IL, Abstract CT037.
Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer. J Natl Cancer Inst. 2017, 109(6): djw297.
The small molecule CDK2 and CDK9 inhibitors CYC065 and CCT68127 are potent inhibitors of MYCN via transcriptional repression. Childhood Cancer Meeting 2016, Sept 5–7, London, UK, Abstract 1-19.
Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo. Br J Cancer 2016. 115:303-11.