Publications
Publications
Cyclacel has contributed to many scientific advancements.
Jul 2021
Kantarjian HM et al., Results of a Randomized Phase 3 Study of Oral Sapacitabine in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia (SEAMLESS). Cancer 2021; doi: 10.1002/cncr.33828.
Apr 2019
Keenan T et al., Expansion of phase 1 study of oral sapacitabine and oral seliciclib in patients with metastatic breast cancer and BRCA1/2 mutations. Proc. Ann. Meeting AACR, 2019, Mar 29–Apr 3; Atlanta, GA, Abstract CT050.
Jan 2017
Kantarjian H et al., Results of a Phase 3 Study of Elderly Patients with Newly Diagnosed AML Treated with Sapacitabine and Decitabine Administered in Alternating Cycles. Blood 2017, 130: Abstract 891.
Jul 2016
Tolaney, SM et al., Phase I study of sapacitabine and seliciclib in patients with advanced solid tumors. J Clin Oncol 34, 2016 (suppl; Abstract 2503).
Jan 2013
Shapiro GI et al., Responses to sequential sapacitabine and seliciclib in patients with BRCA-deficient solid tumors. Proceedings of the 104th Annual Meeting AACR; 2013, Apr 6-10; Washington, DC. Philadelphia, PA: AACR; 2013. Abstract LB-202.
Oct 2012
Kantarjian H et al., Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study. Lancet Oncol. 2012, 13:1096-1104.
Jun 2011
Ravandi F et al., Phase I/II study of sapacitabine and decitabine administered sequentially in elderly patients with newly diagnosed acute myeloid leukaemia. J Clin Oncol 29: 2011 (suppl; Abstract 6587).
Apr 2010
Frame S et al., Understanding the pathways involved in the repair of CNDAC induced DNA damage. Proceedings of the 101st Annual Meeting AACR; 2010, Apr 17-21; Washington DC, Abstract 3502.
Nov 2009
Kantarjian H et al., Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome. J Clin Oncol. 2010, 28:285-291.